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. 2019 Sep 11;4(5):e781. doi: 10.1097/PR9.0000000000000781

Figure 3.

Figure 3.

Effects of ACD and ICD on behavioral reaction (“total response”) to von Frey filaments and a heated contact thermode applied to the cheek. Each stimulus was applied before and 24 hours after each SADBE challenge on the cheek in ICD and ACD groups of male mice. (A) Mean total response to an innocuous von Frey filament of 0.23 mN and mean DS to aversive filaments of 100-µm tip diameter applied at 3 different bending forces (2, 10, and 20 mN). (B) Mean total response to contact with a thermode having an innocuous temperature of 38°C and a contact thermode having a noxious temperature of 52°C. *P < 0.05, **P < 0.01 , ***P < 0.001, ****P < 0.0001 for significant differences between before and after challenge within a group, whereas †P < 0.05, ††P < 0.01, †††P < 0.001, ††††P < 0.0001 indicate significant differences between the 2 groups. Error bars: SD. n = 12 male mice for ICD, n = 11 for ACD. ACD, allergic contact dermatitis; ICD, irritant contact dermatitis.