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. 2019 Nov 29;4:51. doi: 10.1038/s41392-019-0086-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — HOXB13 regulates apoptosis-related proteins in colon cancer cells. a A human apoptosis antibody array was used to detect the expression of apoptosis-related proteins in two pairs of cells (HCT116/sh-HOXB13 and RKO/HOXB13 OE cells and the corresponding controls). A scatter diagram was drawn to show the average expression of proteins in HCT116/sh-HOXB13 and RKO/HOXB13 OE cells compared to the corresponding controls. b Intersection of differentially expressed proteins between the two pairs of cells. c Heat map showing the expression levels of representative differentially expressed proteins from the array data. The color indicates the level of protein expression (low expression (green) and high expression (red)). d Western blotting was performed to detect differentially expressed proteins between the two pairs of cells. e, f GO functional and KEGG analyses were performed to investigate the biological processes (BP) and pathways enriched in HOXB13-related DEGs. The top ten most significantly enriched BP terms and KEGG pathways are shown