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. 2019 Nov 29;4:51. doi: 10.1038/s41392-019-0086-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — HOXB13 expression is downregulated by DNMT3B, which inhibits C-myc expression in RCC. a Analysis of the relationship between HOXB13 and CIMP status based on the GSE39582 dataset. b Comparison of DNMT3B IHC scores in RCC (n = 33) and LCC (n = 28). c Representative images showing HOXB13 and DNMT3B staining in RCC tissues. Scale bars represent 50 μm. d Quantitative analysis of the correlation between HOXB13 and DNMT3B expression in RCC (n = 33) according to IHC staining score. e Representative images showing HOXB13 and C-myc staining in RCC tissues. f Comparison of HOXB13 and C-myc expression in RCC according to IHC scores (n = 33). P1–P4, 4 representative patients. Data are presented as the means ± SDs. **P < 0.01, ***P < 0.001