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. 2019 Nov 28;9:17807. doi: 10.1038/s41598-019-54282-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EMT-TFs are significantly positively correlated with stromal and immune cell abundance in multiple cancer types. (A) Heatmap illustrating Spearman correlation coefficients for selected EMT-TFs and ESTIMATE stromal score across five cancer types (breast (BRCA), colorectal (COAD), lung (LUAD), prostate (PST) and pancreatic (PDAC) adenocarcinoma. (B) Heatmap illustrating Spearman correlation coefficients for selected EMT-TFs and ESTIMATE immune score across same five cancer types. (C) Scatterplot illustrating correlation between ZEB1 expression and stromal score in BRCA dataset. Table shows correlation coefficients for both ER+ and ER− subsets. (D) Comparison of immunohistochemistry-estimated percentage of stromal cells between patients with less or greater than median ZEB1 (z score = −0.3026) mRNA expression (n = 1078 for all BRCA analyses).