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. 2019 Nov 28;9:17798. doi: 10.1038/s41598-019-54167-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EC Accelerate Quiescent NSC Extravasation from Microbead. (A) Schematic overview depicting the transplantation target site (striatum) in the adult mouse brain for control, free cells, and cell encapsulated microbeads with transplantation parameters outlined in (B). (C) Confocal images of GFP-tagged NSC and Hoechst mono- and co-cultures encapsulated in microbeads to observe cell extravasation at 2 days post transplantation and (D) expression of GFP-tagged NSC, Sox2, Ki67, and Hoechst to observe cell proliferation at 3 days post transplantation. Scale bar (25 µm) representative of all images.