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. 2019 Nov 28;9:17833. doi: 10.1038/s41598-019-54436-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Classification of amfepramone (AFP) metabolic phenotypes. (A) Dendrogram generated with Manhattan distance and Ward’s linkage method. (B) Pharmacokinetic profiles of different metabolic phenotypes. Mean peak plasma AFP concentration-time curves after single 75 mg dose of AFP. Data shown are mean ± standard error (SE) concentrations. For both (A,B): slow metabolizers (red), intermediate metabolizers (orange), normal metabolizers (green), and fast metabolizers (blue).