Table 5.

Association between genotypes and metabolizer phenotypes

Gene	Polymorphism	Model	OR (95% CI)	P-Value	Pc-Value
ABCB1	rs1045642	Dominant (C/C vs. C/T + T/T)	C/C: Fast metabolizers	0.013	0.041*
			0.29 (0.11–0.75)
			C/T + T/T: Slow/intermediate/normal metabolizers
			2.19 (0.88–5.45)
CYP3A4	rs224280	Co-dominant	C/T: Fast metabolizers	0.033
CYP3A4	rs224280	Over-dominant (C/T vs. C/C + T/T)	C/C + T/T: slow metabolizers	0.019	0.055
			1.93 (1.36–2.75)
CYP3A4	rs224280	Over-dominant (C/T vs. C/C + T/T)	C/T: Fast metabolizers	0.018	0.049*
			0.38 (0.19–0.77)
			C/C + T/T: Slow/intermediate/normal metabolizers
			2.86 (0.84–9.71)
Combination	rs1045642, rs224280	Dominant (C/C vs. C/T + T/T), Over-dominant (C/T vs. C/C + T/T)	C/C-C/T: Fast metabolizers	0.004	0.014*
			0.14 (0.03–0.64)
Combination	rs1045642, rs224280	Dominant (C/C vs. C/T + T/T), Over-dominant (C/T vs. C/C + T/T)	C/T + T/T-C/C + T/T: Slow metabolizers	0.003	0.012*
			2.64 (1.66–4.20)

^*P-Value supported by logistic regression analysis. OR, odds ratio; CI, confidence interval; Pc, Bonferroni-corrected P-values.