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. 2019 Nov 28;9:17810. doi: 10.1038/s41598-019-54306-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dietary Bßglucans inhibit mitochondrial superoxide production, ADAM17, TNFα, nSMase2 and STING gene expression in circulating leukocytes from healthy adults. Box plot analyses of changes in baseline superoxide production (a), ADAM17 (b), TNFα (c), nSMase2 (d) and STING (e) mRNA levels (each shape represents one individual) in peripheral blood monocytes from 5 healthy adults ingesting 3 g of Bßglucans daily, as slices of barley bread, during 4 weeks. *p < 0.05 and **p < 0.01 vs. Baseline, ^#p < 0.05 vs. 1week. Correlation between leukocyte STING mRNA and serum γ-interferon levels (f) and between leukocyte STING and nSMase2 mRNA levels (g). Each shape represent baseline (●), one week (■) and 4 weeks (▲) values.