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. 2019 Nov 28;9:17810. doi: 10.1038/s41598-019-54306-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-inflammatory vascular protection by dietary BßGlucans. (a) Representative immunostaining for ADAM17 (Inset bars indicate relative scale) in thoracic aortas from 5/6NX rats fed a high P diet with none (CKD; n = 13) or 2 mg of Bßglucans/g diet (CKD + Bßglucans; n = 13) during 4 weeks. (b) Quantification of aortic ADAM17 immunostaining. Box plots represent median (interquartile range) of OD/Area values for all rats in both dietary groups. (c) Aortic ADAM17 and TNFα gene expression; (d) Aortic nSMase2 mRNA (white bars; CKD n = 9; CKD + Bßglucans n = 7) and activity (black bars; CKD n = 13; CKD + Barley n = 11). R.U.: Relative units. Bars and error bars represent mean ± SD; *p < 0.05 vs. CKD.