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. 2019 Nov 28;10:5425. doi: 10.1038/s41467-019-13489-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — On-time initiation of PDZ is derailed in Scrib^f/fPgr^cre/+ uteri. a IF co-localization of ZO-1 and Scrib in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice on day 5 afternoon (1400 h) implantation sites. PDZ represented by ZO-1 is absent in Scrib^f/fPgr^cre/+ mice. b IF co-localization of Sav1 and ZO-1 in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice on day 5 afternoon implantation sites. Sav1 expression is absent in Scrib^f/fPgr^cre/+ mice. c IF co-localization of Lats1 and ZO-1 in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice in day 5 afternoon implantation sites. Lats1 expression is decreased in Scrib^f/fPgr^cre/+ mice. d IF of YAP in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice on day 5 afternoon implantation sites. Scrib^f/fPgr^cre/+ implantation site shows increased levels of nuclear YAP in stroma surrounding the embryo. Scale bar: 200 μm. Asterisks indicate the location of embryos. Each image is a representative of at least three independent experiments. M mesometrial pole, AM antimesometrial pole, le luminal epithelium, st stroma, bv blood vessels.