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. 2019 Nov 28;10:5425. doi: 10.1038/s41467-019-13489-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Scrib deletion in stroma impedes formation of avascular PDZ. a Representative images of implantation sites in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice on day 6. Arrowheads indicate weak implantation sites. b In situ hybridization of Bmp2 in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice implantation sites on day 6. Arrowheads indicate the location of blastocysts. Scale bar: 200 μm. c IF of Ki67 and E-cad in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice on day 6 implantation sites. Insides of dotted lines indicate PDZ, arrowheads indicate Ki67 positive stromal cells in PDZ area. Scale bar: 400 μm. d In situ hybridization of Ang-2 in Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice implantation sites on day 6. Scale bar: 500 μm. e IF of ZO-1 and FLK-1 in day 6 implantation sites of Scrib^f/f, Scrib^f/fLtf^cre/+, and Scrib^f/fPgr^cre/+ mice show blood vessels invaded the PDZ in Scrib^f/fPgr^cre/+ mice as indicated by arrows. Scale bar: 200 μm. Asterisks indicate the location of embryos. Each image is a representative of at least three independent experiments. M mesometrial pole, AM antimesometrial pole, le luminal epithelium, st stroma, bv blood vessels.