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. 2019 Nov 28;9:17747. doi: 10.1038/s41598-019-53700-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Statins specificity of Rab-GTPase inhibition. (a) Top, Typical confocal microscopy images of HEK293T cells over-expressing Rab5-GFP after overnight statin treatment at the indicated concentration in the presence or absence of 10 µM GGPP. Bottom, Summary of Rab5 nucleus/cytoplasm fluorescence ratio of the experiment performed in top panel. (b) Left, typical confocal images of HEK293T cells over-expressing either Rab7-GFP or Rab11-GFP in control conditions, or after 2 μM statin treatment for overnight. Right, Summary of Rab7 and Rab11 nucleus/cytoplasm ratio. Scale bars, 5 μm. *p < 0.05 (number of cells analyzed).