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Schematic on some known mechanisms of how miRNAs can intrinsically control and impact peripheral nerve injury and regeneration. After an injury, the myelin and axons degrade, and Schwann cells dedifferentiate. As these phenomena happen, the molecular regulators (e.g., miRNA-221, miRNA 222, and Let-7) can influence neurite outgrowth and modulate phenotypic changes in Schwann cells, as well as their myelinating capacity, among others.
