Figure 2.

Overview of acute tenotomy and repair procedure, and representative histology of repaired plantaris tendons. (a) Overview of the surgical procedure, demonstrating a tenotomy (dashed black line) and Bunnell repair technique (suture pattern shown in blue) of the plantaris tendon. After the animals recover, inflammation and fibrous scar tissue will accumulate in the area of injury. The representative region of interest (ROI) for histology panels (c–i) is shown in green. (b) Overview of the study design and groups. (c–i) Hematoxylin and eosin histology stained sections from the midsubstance of plantaris tendons from (c) uninjured rats, and from rats treated with 0, 2, or 6 mg/kg of GSK2894631A taken either 7 days (d–f) or 21 days (g–i) after acute tenotomy and repair. Areas of suture or suture resorption are shown with an asterisk. Scale bar for all histological sections is 100 µm