Figure 4.

Effect of decynium‐22 on dialysate 5‐HT and 5‐HIAA concentration during coronary occlusion and reperfusion. In control group (n = 7), 5‐HT increased during coronary occlusion and then immediately decreased after reperfusion, while 5‐HIAA kept the baseline level during coronary occlusion and abruptly increased after reperfusion. In decynium‐22 group (n = 7), background level of 5‐HT rose at baseline and during coronary occlusion and did not return to the baseline level after reperfusion. At baseline and during coronary occlusion 5‐HIAA level was not affected by decynium‐22, however, the increase in 5‐HIAA in the early reperfusion was significantly suppressed. Data are presented as box‐whisker plots. The horizontal line in the box indicates the median, and the dot in the box indicates the mean. #p < .05, versus Control. Two‐way repeated ANOVA followed by Bonferroni's post‐test