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. 2019 Nov 28;10:5421. doi: 10.1038/s41467-019-13204-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — iRFA induces local inflammation and upregulates genes associated with immune suppression. a Difference in RNAseq of the untreated and iRFA-treated CT26 tumors on day 3 after iRFA (n = 3). Red and green colors indicate upregulated or downregulated genes. b Overlap in gene expression profiles between untreated and iRFA-treated tumors (n = 3). c Significant enrichment in GO terms (top 20). d Heatmap of mean fold-change of in cytokines and chemokines and genes-associated immunosuppression (n = 3). Red and blue colors indicate upregulated or downregulated genes. e Bioluminescence imaging of BALB/C-Tg (Tnfa-luc)-Xen mice inoculated with complete or incomplete ablation of the implanted CT26 tumors (red circle: targeted tumor pre-RFA white arrow: necrotic zone, red arrow: residual tumor). Red and blue represent high or low fluorescence intensity (n = 3).