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. 2019 Nov 28;9:17869. doi: 10.1038/s41598-019-54190-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) $Y_{C_{5}}^{V S}$ for the 14 experimental conditions for C₅. ↑ shows when stability is reached for unbalanced cases (cohort 1). (b) Absolute differences in Youden index between $Y_{C_{5}}^{V S}$ and $Y_{C_{5}}^{T E S}$ for C₅ (cohort 1). (c) AUC on VS for the 14 experimental conditions for C₅. (d) Absolute differences in AUC index between VS and TES for C₅ (cohort 1).