Figure 2.

Effects of single or combined treatment with ipragliflozin and pioglitazone on glucose tolerance and insulin resistance in type 2 diabetic mice with NASH. Time course of changes in the (a) blood glucose and (b) plasma insulin levels, and area under the blood glucose and plasma insulin concentration–time curve (AUC) during the oral glucose tolerance test (OGTT). The (c) Matsuda index and (d) disposition index were used as parameters of insulin resistance and secretion, respectively. OGTT was performed at Week 3 of repeated administration. Values indicate mean ± SEM for six animals per group. *p < .05 versus normal group, ^# p < .05 versus vehicle group, ^$ p < .05 versus pioglitazone (10 mg/kg) group