Figure 2. Apyrase prevents the systemic and local increase in leukocytes in infected mice.
Mice were intraperitoneally injected with LPS (0.5 mg/mouse), apyrase (0.6 IU/g bodyweight), or saline. Two hours later, a bolus injection (i.p.) of 1×106 live E. coli was administered. After another hour, peritoneal lavages and blood samples were collected and PMNs (A and B) and white blood cell counts (C and D) were determined (n= 3–10; #p<0.05 vs. E. coli, one-way ANOVA; *p<0.05 vs. LPS + E. coli, one-way ANOVA).