Table 7:

Relationship between ELISPOT Measures of immunosuppression and any viral Infection

Mechanistic Assays	All Subjects (N=60)* n (%)	Any Viral Infection (N=52) n (%)	No Viral Infection (N=8) n (%)	P-value
High immunosuppression per ELISPOT (at least one positive** sample)
Yes	43(71.7)	41(78.8)	2(25.0)	0.003
No	16(26.7)	10(19.2)	6(75.0)
Number of High immunosuppression samples** per Subject
0	16(26.7)	10(19.2)	6(75.0)	0.055
1	9(15.0)	9(17.3)	0
2	7(11.7)	6(11.5)	1(12.5)
3	7(11.7)	7(13.5)	0
4	11(18.3)	11(21.2)	0
5	5( 8.3)	5( 9.6)	0
6	3( 5.0)	2( 3.8)	1(12.5)
10	1( 1.7)	1( 1.9)	0

^*One subject met the composite endpoint without having any viral specimens obtained.

^**Samples were considered positive for high immunosuppression if the response to positive control (phytohemagglutinin, PHA) was less than 100 spots and cell viability was > 50%.