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. 2019 May 29;34(1):196–209. doi: 10.1038/s41375-019-0493-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Qualitative and quantitative changes in exosomes derived from HDAC3 KD HS-5 plus MM1S.Luc co-culture supernatant contributes to MM cell growth arrest. a Nanoparticle tracking analysis (NTA) showing the mean/modal size and concentration of exosomes in the supernatant of HDAC3 KD HS-5 versus scramble HS-5, co-cultured with MM1S.Luc. The data was normalized to cell count for each condition. b siRNA knockdown of TSG101 in MM.1S resulted in decreased exosome secretion as measured by NTA. Data was normalized to cell count for each condition. c Exosomes isolated from HDAC3-silenced HS-5 triggers significant MM1S.Luc growth inhibition compared to exosomes isolated from scramble siRNA HS-5 (65.7% decrease in MM1S.Luc proliferation in HS-5 (HDAC3 KD) alone, P < 0.05)