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. 2019 May 29;34(1):196–209. doi: 10.1038/s41375-019-0493-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — HDAC3 expression in BMSC is essential for its MM growth-supporting effects both in a 3D-in vitro co-culture model and in vivo. a MM1S.Luc proliferation in a 3D system alone or in co-culture with WT or HDAC3 KO HS-5. b Bioluminescence imaging of mice inoculated subcutaneously with MM1S.Luc cells and WT (left panels) or HDAC3 KO (right panels) HS-5. Five representative mice per group are shown. c Luciferase activity of tumor in each cohort was quantified using the Living Image software. Data represent mean ± s.d. (P value > 0.05). d The overall survival of mice inoculated with HDAC3 KO HS-5 plus MM1S.Luc was significantly higher compared to mice inoculated with WT HS-5 plus MM1S.Luc (median OS: 70 (WT) vs. 60 (KO) days; P = 0.0094) (N = 8 each group)