Fig. 7.

Schema of proposed molecular mechanisms underlying anti-MM effect of HDAC3 targeting in BMSC. On one hand, HDAC3 targeting in BMSC has anti-MM effect by increasing sgp130 secretion, via a paracrine-autocrine loop, which acts as a decoy receptor to prevent binding of the IL6/IL6R complex to CD130. The resulting abrogation of IL-6 trans-signaling and downstream STAT3 signaling leads to decreased MM proliferation. On the other, HDAC3 silencing in BMSCs leads to decreased exosome secretion associated to downregulation of TSG101 and qualitative changes in miRNA content, resulting in MM growth inhibition