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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Nature. 2019 Nov 6;575(7784):674–678. doi: 10.1038/s41586-019-1735-9

Extended Data Figure 5 |. Interaction with PA14_01130 distorts the predicted nucleotide acceptor site of PA14_01140tox.

Extended Data Figure 5 |

Structural alignment between PA14_01140tox-PA14_01130 complex and the (p)ppGpp synthetase RelP bound to the non-hydrolysable ATP analog AMPCPP and a GTP acceptor nucleotide (PDB code 6EWZ)40. Two C-terminal α-helices of PA14_01140tox that align with the GTP binding site of RelP are rotated approximately 30° as a consequence of their interaction with PA14_01130 (black arrow). Colours corresponding to each protein model are indicated.