Table 1.
Clinical, pathological and molecular features of colorectal carcinomas according to CNN3 expression status
| Clinical and pathological features | Total |
CNN3 expression |
P value | ||
| Negative, n (%) | Positive, n (%) | ||||
| All cases | 57 | 37 (65) | 20 (35) | ||
| Gender | male | 32 | 21 (56) | 11 (34) | NS |
| female | 25 | 16 (64) | 9 (36) | ||
| Age in yr | ≤ 50 | 35 | 23 (66) | 12 (34) | NS |
| > 50 | 22 | 14 (64) | 8 (36) | ||
| Histological variant | adenocarcinoma | 44 | 27 (61) | 17 (39) | NS |
| mucinous adenocarcinoma | 9 | 8 (89) | 1 (11) | ||
| others1 | 4 | 2 (50) | 2 (50) | ||
| Differentiation/grade2 | well/moderate | 18 | 12 (67) | 6 (33) | NS |
| poor | 33 | 22 (67) | 11 (33) | ||
| Stage2 | early (I and II) | 32 | 20 (63.5) | 12 (37.5) | NS |
| late (III and IV) | 23 | 15 (65) | 8 (35) | ||
| Extracellular mucin | present | 21 | 13 (62) | 8 (38) | NS |
| absent | 36 | 24 (67) | 12 (33) | ||
| MSI status2 | MSI | 15 | 8 (53) | 7 (47) | NS |
| MSS | 38 | 25 (66) | 13 (34) | ||
| p53 | negative | 28 | 19 (68) | 9 (32) | NS |
| stabilized | 29 | 18 (62) | 11 (38) | ||
Other subtypes were: 1 medullary carcinoma, 1 squamous cell carcinoma [both were negative for Calponin 3 (CNN3)], 1 signet ring carcinoma, and 1 undifferentiated carcinoma (both were positive for CNN3);
Variation in total numbers were due to unavailable data. Extracellular mucin was detected morphologically after staining with hematoxylin and eosin as well as Periodic Acid-Schiff. Microsatellite instability was detected by the microsatellite markers BAT25 and BAT26; p53 status was characterized by immunohistochemical detection of protein stabilization[21,22]. NS: Not significant; MSI: Microsatellite instability; MSS: Microsatellite stable; CNN3: Calponin 3.