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. 2019 Nov 22;10:822. doi: 10.3389/fendo.2019.00822

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Copyright © 2019 Khan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure and domains of IGFBP-2. IGFBP-2 consists of N-terminal and C-terminal regions linked by a linker domain. Both the N- and C-terminal have one IGF-binding domain. There is a proteolytic cleavage site between the two terminals. The HBD-1, HBD-2, and RDG domains are located in the cysteine-rich C-terminal region. The nuclear localization domain is adjacent to the HBD1 domain.