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A Schematic Diagram Showing Targets of let-7 in Cancer
Let-7 causes translational suppression of HMGA2, MYC, TRAIL, CASP3, and Lin28B. Blockage of let-7 biogenesis will consequently result in an upregulation of each of these targets. Lin28B and TRAIL-receptor 2 further contribute to the inhibition of let-7 biogenesis. Collectively, upregulation of these targets results in a proliferative, invasive, and therapeutically resistant phenotype.
