Table 3.
A Summary of the let-7 Expression Profile in Various Malignancies
| Cancer | Cell Line Tested | Expression | Reference |
|---|---|---|---|
| Breast | MCF10A-HER2/3, BT474, SKBR3, MCF10A-NeuNT, SUM159, SUM1315 | ↑ SHP2 | 106 |
| ↑ ZEB1 | |||
| ↑ MYC | |||
| ↑ Lin28B | |||
| ↑ RAS | |||
| ↓ Let-7 | |||
| Lung | NSCLC | ↑ Lin28B | 107 |
| ↓ Let-7 | |||
| Multiple myeloma | MOLP-8, KMS12BM, RPMI8226, KMM-1 | ↑ Lin28B | 38 |
| ↑ MYC | |||
| ↓ Let-7 | |||
| Neuroblastoma | BE(2)-C, SMS-KCNR, CHLA90 | ↑ Lin28B | 108 |
| ↑ MYCN | |||
| ↓ Let-7 | |||
| Oral | OSCC | ↑ Lin28B | 109 |
| ↑ ARID3B | |||
| ↑ HMGA2 | |||
| ↑ OCT4 | |||
| ↑ SOX2 | |||
| ↓ Let-7 | |||
| Ovarian | ES-2 | ↑ Lin28 | 110 |
| ↑ IGF2BP1 | |||
| ↑ HMGA2 | |||
| ↓ Let-7 | |||
| Pancreatic | PDAC | ↑ Lin28B | 111 |
| ↓ SIRT6 | |||
| ↓ Let-7 | |||
| Prostate | PrEC, RWPE-1, LNCaP, DU145, PC3 | ↑ Lin28A | 46 |
| ↑ Lin28B | |||
| ↓ ESE3/EHF | |||
| ↓ Let-7 |
ARID3B, AT-rich interactive domain 3B; IGF2BP1, insulin-like growth factor 2 mRNA-binding protein 1; NSCLC, non-small-cell lung carcinoma; OSCC, oral squamous cell carcinoma; PDAC, pancreatic ductal adenocarcinoma; SIRT6, sirtuin 6.