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. 2019 Oct 22;18:903–915. doi: 10.1016/j.omtn.2019.10.014

Figure 6.

Figure 6

miR-29a-3p Affects TNFα-Induced VCAM-1, ICAM-1, and E-selectin Expression by Targeting TNF-R1

(A–C) The mRNA levels of VCAM-1 (A), ICAM-1 (B), and E-selectin (C) were detected in pHUVECs transfected with miR-29a-3p or/and the plasmid containing human TNFRSF1A (TNF-R1 overexpression). (D–F) The mRNA levels of VCAM-1 (D), ICAM-1 (E), and E-selectin (F) were measured in pHUVECs transfected with miR-29a-3p inhibitor or/and TNF-R1-siRNA. After 24 h, the cells were treated with TNFα for 3 h before collection. A scrambled sequence was used as a negative control (NC). Each test was performed three times. Error bars are defined as the SD. *p < 0.05 and **p < 0.01 indicate statistically significant differences. miR-29a-3p, cells transfected with miR-29a-3p mimic.