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. 2019 Nov 22;10:1434. doi: 10.3389/fphys.2019.01434

Figure 1.

Figure 1

Hypertension in TASK−/− mice. Continuous telemetric recordings of SBP, DBP, and HR over 24-h period were performed in TASK+/+ and TASK−/− mice (n = 13 for each genotype). Measurements were made hourly over 24 h. (A–C) Dynamic SBP, DBP, and HR over 24 h. SBP and DBP were significantly higher at each time point over 24 h in TASK−/− mice compared to TASK+/+ mice (p < 0.05, two-way ANOVA with Fisher’s LSD post hoc test). HR measured over 24 h in TASK−/− mice was not different from control mice, except for higher HR at specific time points (p < 0.05 as indicated by Φ, two-way ANOVA with Fisher’s LSD post hoc test). (D–F) 24-h average SBP, DBP, and HR. ****p < 0.0001 as indicated, unpaired t test. (G) Circadian changes in plasma Aldo and arterial pressure. Top panel: plasma level of Aldo was measured at 6:00, 12:00, 18:00, and 24:00. n = 16 mice for each genotype. Bottom panel: telemetric recordings of SBP. n = 13 mice for each genotype. *p < 0.05, **p < 0.01, ****p < 0.0001 by two-way ANOVA with Fisher’s LSD post hoc test, TASK−/− versus TASK+/+ mice. SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; BPM, beat per minute.