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. 2019 Nov 22;10:1434. doi: 10.3389/fphys.2019.01434

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Copyright © 2019 Shi, Yuan, Wang, Wang, Liu, Tian, Guo, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of central MR blockade on arterial pressure. SPIR was centrally given via an ICV injection once daily for 7 days in TASK^+/+ and TASK^−/− mice (n = 8 for each genotype). (A) Shows a schematic diagram of ICV injection (left) and a half slice image (right) of ICV injection of the Evans Blue. Application of SPIR considerably lowered 24-h average SBP (B) and DBP (C) TASK^−/− mice, without significant impact on TASK^+/+ mice. No obvious difference was found in HR (D) in both genotypes. ^**p < 0.01, ^***p < 0.001 as indicated by two-way ANOVA with Tukey’s multiple comparisons test. ICV, intracerebroventricular; LV, lateral ventricle; 3V, third ventricle.