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. 2019 Nov 22;10:1434. doi: 10.3389/fphys.2019.01434

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Copyright © 2019 Shi, Yuan, Wang, Wang, Liu, Tian, Guo, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impairment of baroreflex gain in TASK^−/− mice. The baroreflex gain was calculated based on the change in SBP (ΔSBP) and HR (ΔHR) during intravenous injection of PE (10 and 20 μg/kg) and during intravenous injection of SNP (30 and 60 μg/kg) in TASK^+/+ mice (n = 18 mice/70 responses), TASK ^−/− mice (n = 12 mice/50 responses), TASK^−/− mice with gavage of SPIR (n = 10 mice/48 responses), and TASK^−/− mice with ICV injection of SPIR (n = 12 mice/45 responses), respectively. (A,B) Bradycardiac rather than tachycardiac gain was significantly decreased in TASK^−/− mice relative to TASK^+/+ mice. ^****p < 0.0001 as indicated by Kruskal-Wallis test followed by Dunn’s multiple comparisons test. (C) The baroreflex curve showing individual data points for the change in heart rate (ΔHR) in response to induced changes in SBP (ΔSBP).