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. 2019 Nov 22;9:1283. doi: 10.3389/fonc.2019.01283

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Copyright © 2019 Li, Dai, Gong, Song, Tai and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of immunoproteasome rescues the protein expression of CDK15. (A) CDK15 protein levels were detected in three breast cancer cell lines when PA28α and/or PA28β was knocked down by siRNA. (B) CDK15 protein expression was observed in three breast cancer cell lines when β5i was stably silenced by shRNA. (C) Cell invasive ability was observed in vector control and β5i-knockdown breast cancer cells. Representative images and quantification data are shown (**P < 0.005; ***P < 0.001).