Table 2.

Univariable and multivariable analysis of factors associated with OS (overall SILIUS)

Parameter		Univariable analysis		Multivariable analysis
HR (95% CI)	p value	HR (95% CI)	p value
Treatment (SOR+HAIC vs. SOR)	0.88 (0.63–1.23)	0.4521
Response (CR+PR vs. SD+PD)	0.39 (0.26–0.58)	<0.0001	0.37 (0.24–0.57)	<0.0001
Age (≥65 vs. <65)	1.25 (0.87–1.78)	0.2245
Sex (male vs. female)	0.76 (0.47–1.22)	0.2575
PS (1 vs. 0)	2.17 (1.34–3.51)	0.0015	1.88 (1.15–3.08)	0.0122
Vp (Vp1–4 vs. Vp0)	0.88 (0.63–1.22)	0.4384
Extrahepatic spread (yes vs. no)	1.03 (0.70–1.51)	0.8981
HBV (yes vs. no)	1.15 (0.78–1.71)	0.4753
HCV (yes vs. no)	0.93 (0.66–1.30)	0.6741
Albumin (≥3.6 vs. <3.6 mg/dL)	0.80 (0.58–1.12)	0.1976
Bilirubin (≥0.8 vs. <0.8 mg/dL)	1.57 (1.12–2.21)	0.0086	1.34 (0.95–1.89)	0.0995
ALBI grade (grade 2 vs. grade 1)	1.26 (0.88–1.79)	0.2019
AFP (≥400 vs. <400 ng/mL)	1.68 (1.20–2.36)	0.0024	1.84 (1.31–2.60)	0.0005
DCP (≥2,050 vs. <2,050 mAU/mL)	1.05 (0.75–1.47)	0.7610

All covariates were time-fixed except for response, which was time-dependent. OS, overall survival; ALBI grade, albumin-bilirubin grade; AFP, alfa-fetoprotein; DCP, des-γ-carboxy prothrombin.