Table 3.

Univariable and multivariable analysis of factors associated with OS (sorafenib alone group)

Parameter		Univariable analysis		Multivariable analysis
HR (95% CI)	p value	HR (95% CI)	p value
Response (CR+PR vs. SD+PD)	0.37 (0.19–0.71)	0.0029	0.38 (0.18–0.84)	0.0164
Age (≥65 vs. <65)	0.94 (0.57–1.53)	0.7936
Sex (male vs. female)	1.06 (0.56–2.01)	0.8550
PS (1 vs. 0)	1.95 (1.00–3.80)	0.0509	1.88 (0.91–3.88)	0.0880
Vp (Vp1–4 vs. Vp0)	0.90 (0.57–1.42)	0.6502
Extrahepatic spread (yes vs. no)	1.14 (0.68–1.92)	0.6205
HBV (yes vs. no)	1.77 (1.01–3.10)	0.0472	1.39 (0.71–2.72)	0.3381
HCV (yes vs. no)	0.68 (0.43–1.08)	0.0997	0.86 (0.50–1.49)	0.5989
Albumin (≥3.6 vs. <3.6 mg/dL)	1.10 (0.70–1.74)	0.6839
Bilirubin (≥0.8 vs. <0.8 mg/dL)	1.94 (1.21–3.09)	0.0055	1.35 (0.80–2.26)	0.2608
ALBI grade (grade 2 vs. grade 1)	0.92 (0.58–1.45)	0.7071
AFP (≥400 vs. <400 ng/mL)	1.48 (0.94–2.33)	0.0884	1.70 (1.02–2.83)	0.0406
DCP (≥2,050 vs. <2,050 mAU/mL)	1.04 (0.67–1.64)	0.8500

All covariates were time-fixed except for response, which was time-dependent. OS, overall survival; ALBI grade, albumin-bilirubin grade; AFP, alfa-fetoprotein; DCP, des-γ-carboxy prothrombin.