Table 4.

Univariable and multivariable analysis of factors associated with OS (sorafenib plus HAIC group)

Parameter		Univariable analysis		Multivariable analysis
HR (95% CI)	p value	HR (95% CI)	p value
Response (CR+PR vs. SD+PD)	0.36 (0.21–0.64)	0.0004	0.32 (0.18–0.59)	0.0003
Age (≥65 vs. <65)	1.63 (0.97–2.73)	0.0651	1.70 (0.94–3.08)	0.0788
Sex (male vs. female)	0.43 (0.21–0.89)	0.0231	0.67 (0.28–1.61)	0.3730
PS (1 vs. 0)	2.66 (1.31–5.37)	0.0066	1.54 (0.65–3.69)	0.3284
Vp (Vp1–4 vs. Vp0)	0.87 (0.53–1.42)	0.5777
Extrahepatic spread (yes vs. no)	0.94 (0.53–1.66)	0.8213
HBV (yes vs. no)	0.87 (0.50–1.52)	0.6276
HCV (yes vs. no)	1.30 (0.79–2.13)	0.2981
Albumin (≥3.6 vs. <3.6 mg/dL)	0.55 (0.33–0.90)	0.0169	0.98 (0.48–1.98)	0.9446
Bilirubin (≥0.8 vs. <0.8 mg/dL)	1.22 (0.74–2.00)	0.4348
ALBI grade (grade 2 vs. grade 1)	1.95 (1.11–3.45)	0.0208	1.66 (0.78–3.53)	0.1855
AFP (≥400 vs. <400 ng/mL)	2.06 (1.24–3.45)	0.0056	2.46 (1.33–4.55)	0.0043
DCP (≥2,050 vs. <2,050 mAU/mL)	1.11 (0.67–1.84)	0.6824

All covariates were time-fixed except for response, which was time-dependent. OS, overall survival; ALBI grade, albumin-bilirubin grade; AFP, alfa-fetoprotein; DCP, des-γ-carboxy prothrombin.