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. 2019 Nov 28;14:273. doi: 10.1186/s13023-019-1225-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Cognitive outcomes in terms of IQ and overall z -score in our cognitive battery in relation to metabolic control. Panel A shows metabolic control in terms of Phe average levels in childhood and later on. Panel B shows metabolic control in term of Phe variation in childhood and later on. Note z-scores are depicted in figure so that both high IQ and high z-scores indicate good performance. The top horizontal line indicates average performance according to control group. The bottom horizontal line indicates performance = < 1SD from control average (FIQ for controls = 112.3; SD = 11.3; cut off 1 SD = 101). The black dots correspond to poor scores. The vertical lines indicate possible safety criteria (for Phe average < 360 in childhood < 600 afterwards; for SD < 180)