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. 2019 Nov 28;14:273. doi: 10.1186/s13023-019-1225-z

Table 2.

Cognitive performance of the PKU group (English and Italian PKU participants; N = 56). Z scores calculated from respective control groups (N = 30 and N = 19). To facilitate interpretation, for all scores, higher Z-score reflect worse performance. Scores in bold are significantly higher than expected. ms. = milliseconds; sec. = seconds

PKU Overall Z score
Mean SD Diff from controls (t-test)
IQ 0.8 1.3 p < .001
Visual attention RTs
 Simple Detection - ms. 0.3 1 n.s.
 Detention with Distractors – ms. 0.8 1.6 p < .01
 Feature Search – ms. 1.5 2.3 p < .001
 Conjunction Search m. 1.2 1.7 p < .001
Visual attention accuracy
 Detention with Distractors - % errors 0.2 1 n.s.
 Feature Search - % errors 0.2 2.6 n.s
 Conjunction Search - % errors −0.1 0.8 n.s
Visuo-motor coordination
 Pegboard (sec.) 0.9 1.9 p < .01
 Digit Symbol (%errors in 90 s.) 0.7 1.2 p < .01
 Trail-Making Test A: (sec.) 0.8 1.9 p < .01
Executive functions
  WCST
 Total errors 0.4 1.6 n.s.
 Perseverative responses 0.1 1.1 n.s.
 N of Completed Categories 0.5 1.9 p = .06
Trail-Making Tests
 B (sec.) 0.6 1.5 p = .01
 B-A (sec.) 0.5 1.7 p = .06
Verbal Fluency
 Letter (correct answers) 0.6 1 p < .01
 Semantic (correct answers) 0.8 1.3 p < .001
Short term memory
 Digit span 0.3 1.1 n.s.
 Corsi Block span 0.0 1.1 n.s.
Sustained attention
 RVP (% of errors) 0.7 1.3 p < .01
Learning
Rey Auditory Verbal Learning Test
 Trial A1-A5 (% errors) 0.2 1.2 n.s.
 Retention (% errors A6) 0.3 1.4 n.s.
 Delayed Recall (% errors) 0.3 1.3 n.s.
Paired Associate Visual learning
 (% errors) 0.7 1.9 p = .02
Overall (excluding IQ)
 Mean 0.5 0.8 p < .001