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. 2019 Nov 28;14:273. doi: 10.1186/s13023-019-1225-z

Table 4.

Regression analyses predicting cognitive outcomes from Phe variation (SD) and Phe average entered either at the same step (forward method; set A) or at different steps (set b). Phe variation and Phe average are computed across the life-span. Coefficient and p refer to best model

Dependent variable R2 Adj R2 Predictors stand β p R2 change
Analysis-A
 Full IQ Step 1 0.16 0.14 Education .28 .01
Step 2 0.39 0.37 Phe SD −0.5 <.001
Phe average
 Mean z-score Step 1 0.09 0.08 Education −19 .09
Step 2 0.42 0.39 Phe SD .46 <.001
Phe average .23 .049
Analysis B
 Full IQ Step 1 0.05 0.03 Phe average −.03 n.s.
Step 2 0.32 0.29 Phe SD −.55 <.001 0.27
 Mean z-score Step 1 0.16 0.14 Phe average .22 .06
Step 2 0.39 0.36 Phe SD .51 <.001 0.23