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. 2019 Nov 28;14:273. doi: 10.1186/s13023-019-1225-z

Table 6.

Number and percentages of poor cognitive scores in individuals who have followed or not followed European guidelines (Phe average < 360 in childhood; < 600 after that); Poor cognitive scores = > 1 SD worse than the controls. Z-score = mean z score in our cognitive battery

Childhood 0–10 Adolescence/Adult 11+
Guidelines Diff. χ2 Guidelines Diff. χ2
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Phe AVERAGE Phe < 360 Phe > 360 p Phe < 600 Phe > 600 p
IQ N 10/22 16/28 4/15 23/41
% 45.5 57.1 11.7 .30 26.7 56.1 29.4 .05
z-score N 3/22 9/28 0/15 12/41
% 13.6 26.5 12.8 .12 0 29.3 29.3 .01
Phe SD Phe < 180 Phe > 180 Phe < 180 Phe > 180
IQ N 5/14 21/34 15/38 11/18
% 35.7 61.8 26.1 .09 42.2 61.1 19.0 .11
z-score N 0/14 12/34 5/38 -7/18
% 0 35.3 35.3 .008 13.6 38.9 25.7 .03