Table 7.
Performance of potentially exceptional participants with good cognition in spite of poor metabolic control or vice-versa poor cognition in spite of good control (see text for further explanation). Childhood Phe results for PKU108 are not available
| Good cognition but poor adult control | |||
|---|---|---|---|
| PKU4 | PKU107 | PKU108 | |
| IT | UK | UK | |
| Age | 24 | 40 | 27 |
| Education (in years) | 13 | 14 | 16 |
| Gender (M/F) | M | M | M |
| Full IQ | 109 | 117 | 126 |
| Feature search RT | −0.1 | −0.3 | −1.1 |
| Conjoined search RT | 0.1 | −0.5 | −1.4 |
| Pegboard | 0.1 | −0.6 | 1.1 |
| Average Z score | 0.1 | 0.0 | −0.2 |
| % z score = > 1.5 | 4.2 | 8.3 | 8.3 |
| Childhood (0–10 y) | |||
| Phe Average Median | 498 | 425 | – |
| Phe Variation | 181 | 213 | – |
| Adolescence (11–16 y) | |||
| Phe Average Median | 634 | 622 | 845 |
| Phe Variation | 634 | 113 | 150 |
| Adulthood (17 y +) | |||
| Phe Average Median | 1067 | 1115 | 1000 |
| Phe Variation | 239 | 114 | 137 |
| Lifetime | |||
| Phe Average Median | 672 | 978 | 975 |
| Phe Variation | 169 | 148 | 139 |
| Current Phe | 1635 | 1080 | 685 |