Table 3.
Definition criteria and antibiotic panel for Acinetobacter baumannii complex
| Antimicrobial category | ECDC-MDR | KRINKO-3MRGN | KRINKO-4MRGN | UHZ-MDR |
|---|---|---|---|---|
| Antipseudomonal penicillins | Piperacillin/ tazobactam or ticarcillin/ clavulanic acid | Piperacillin a) | Piperacillin a) | Piperacillin/ tazobactam |
| Extended spectrum cephalosporins | Cefotaxime or ceftriaxone or ceftazidime or cefepime | Cefotaxime b) or ceftazidime | Cefotaxime b) or ceftazidime | Ceftazidime and cefepime |
| Carbapenems | Imipenem or meropenem or doripenem | Imipenem or meropenem | Imipenem or meropenem | Imipenem or meropenem |
| Quinolones | Ciprofloxacin or levofloxacin | Ciprofloxacin | Ciprofloxacin | Ciprofloxacin and levofloxacin |
| Aminoglycosides | Amikacin or gentamicin or tobramycin or netilmicin | ≥2 of: Amikacin, gentamicin, tobramycin | ||
| Folate pathway inhibitors | Trimethoprim/ sulphamethoxazol | |||
| Penicillins plus beta-lactamase-inhibitors | Ampicillin/ sulbactam | |||
| Polymyxins | Colistin or polymyxin B | |||
| Tetracyclines | Tetracycline or doxycycline or minocycline | |||
| Definition of MDR | Resistant to ≥3 categories | Resistant to antipseudomonal penicillin and cephalosporin-group and quinolone and susceptible to carbapenems | Resistant to all 4 categories or If a carbapenem is resistant all Acinetobacter are interpreted as 4MRGN or Acinetobacter with carbapenemase production | Resistant to 3 out of 5 categories |
Abbreviations: ECDC-MDR Multidrug resistance according to the European Centre for Disease Prevention and Control, KRINKO-3MRGN Multidrug resistance to three antibiotic categories according to the German Commission of Hospital Hygiene and Infection Prevention, KRINKO-4MRGN Multidrug resistance to four antibiotic categories according to the German Commission of Hospital Hygiene and Infection Prevention, MDR Multidrug resistant, UHZ-MDR multidrug resistance according to University Hospital Zurich guidelines
a) as piperacillin/tazobactam and not piperacillin was tested: Resistance to ceftriaxone and/or ceftazidime was interpreted as resistance to piperacillin (15)
b) as cefotaxime was not tested, ceftazidime replaces cefotaxime
Italic font: not tested in UHZ or only tested by MIC under special circumstances