Table 1.
Demographic and clinical characteristics of TREM2 rare variant carriers and non-carriers
| TREM2 non-carriers (n = 49) | TREM2 rare variant carriers (n = 48) | TREM2 rare variant carriers | ||||
|---|---|---|---|---|---|---|
| p.R47H (n = 26) | p.T96K (n = 8) | p.D87N (n = 5) | Others (n = 9) | |||
| Age, years (SD) | 76.1 (6.7) | 75.2 (7.3) | 73.9 (8.4) | 76.6 (4.8) | 72.4 (6.8) | 76.9 (4.1) |
| Female, n (%) | 27/49 (55.1) | 26/48 (54.2) | 12 (46.2) | 5 (55.5) | 3 (60) | 6 (75) |
| APOE ɛ4 carriers, n (%) | 24 (68.6)a | 21 (59.7)b | 11 | 3 | 1 | 6 |
| MMSE, n (SD) | 23.3 (5.0) | 23.1 (6.4) | 21 (7.5) | 25 (5.0) | 28.8 (4.5) | 24.7 (2.3) |
| Diagnosis, n (%) | AD, 31/49 (63.3); MCI, 8/49 (16.3); Ctrl, 10/49 (20.4) | AD, 28/48 (58.4); MCI, 10/48 (20.8); Ctrl, 10/48 (20.8) | 18/26 (69); 4/26 (15.5); 4/26 (15.5) | 2/9 (25.0); 3/9 (37.5); 3/9 (37.5) | 1/5 (16.7); 2/5 (33.3); 2/5 (50.0) | 7/9 (87.5); 1/9 (12.5); 0/9 |
| sTREM2, ng/L (SD) | 8750 (5265) | 7346 (5526) | 7294 (6791) | 8761.8 (4840) | 6431 (4107) | 7009 (1889) |
| NFL, ng/L (SD) | 26.1 (17.1) | 24.6 (19.1) | 25.7 (23.8) | 25.2 (17.8) | 23.1 (7.7) | 21.3 (7.6) |
a = 14 individuals with missing APOE status
b = 13 individuals with missing APOE status