Fig. 7.

CD90 is positively correlated with CyclinD1 but negatively with Leptin in mouse and human WAT. a–c The expression of CD90 (a) was analyzed in inguinal SAT and epididymal VAT from mice fed on normal diet (GSE53307, n = 12); the correlations of CD90 expression with CyclinD1 (b) and Leptin (c) expression were analyzed in WAT (inguinal, axillary SAT and epididymal, mesenteric VAT). d, e The correlations of CD90 expression with CyclinD1 (d) and Leptin (e) expression were analyzed in epididymal and mesenteric VAT from mice fed on normal or high-fat diet for 2, 4, 8, 20, and 24 weeks (GSE39549, n = 40). f–j The correlations of CD90 expression with CyclinD1 (f) and Leptin (g) expression were analyzed in epididymal VAT (adipocyte and SVC fractions) from mice fed on short term of normal or high-fat diet (GSE65557, n = 18); the expression of CD90 (h) and its correlations with CyclinD1 were analyzed on SVCs (i) and adipocytes (j). k, l The correlations of CD90 expression with CyclinD1 expression (k) and BMI (l) were analyzed in abdominal SAT from human subjects with normal or impaired glucose tolerance, or type 2 diabetes (GSE27951, n = 33). m The correlation of CD90 expression with CyclinD1 expression was analyzed in SAT and omental VAT from obese patients who were insulin sensitive or resistant (GSE15773, n = 19). n–p The expression of CD90 (n) and its correlation with CyclinD1 (o) were analyzed in WAT (SAT and omental VAT) from obese patients (GSE20950, n = 39); the correlation of CD90 with Leptin (p) was analyzed in omental VAT from obese patients with insulin resistance. *P < 0.05, **P < 0.01, ***P < 0.001