Fig. 6.

rhMG53 and hUC-MSC treatment reverse neurologic function impairments and relieve anxiety and depressive-like behavior in mice after TBI. a Time-dependent changes in body weight of TBI mice subjected to different treatments. b mNSS assessments at different stages of TBI recovery. c Representative swimming trajectories during the MWM test. Quantification from the MWM was for escape latency (d), number of crossings (e), and time spent in the target quadrant (f). g The discrimination index in the novel object recognition test. Immobility time was assessed using forced swimming test (h) and the tail suspension test (i). The sucrose preference index (j) was measured using sucrose preference test. k Assessment of conflict-based anxiety as time to enter the center during novelty suppressed feeding test. Assessment of exploratory drive. Total number of rearings (l) and total distance traveled (m) were recorded during open-field test. Data were presented as mean ± SEM. n = 10 per group. *p < 0.05, compared with TBI group; ^#p < 0.05, compared with MG53 + MSC group