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. 2019 Nov 29;17:397. doi: 10.1186/s12967-019-02136-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of cryopreservation on BM-MSC in terms of cellular attributes and function. From the systematic analysis performed, cryopreservation appears to influence viability and apoptosis, cellular attachment, immunomodulation and metabolism (cell schematics shown in blue on right-hand side). Whereas, no common significant effects mediated by cryopreservation have been documented in proliferation, morphology, differentiation or immunophenotyping (cell schematics given in green, red, orange and black on the left-hand side)