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. 2019 Nov 28;14:272. doi: 10.1186/s13023-019-1192-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Protein profiles of CPAM cyst epithelium, bronchi, alveoli and fetal tissue. Proteins were obtained by microlaser dissection from 3 different patients. a-c Hierarchical clustering was based on the top 50 more abundant proteins. a. Comparison of proteomic profiles from the epithelial lining of CPAM 1 and CPAM 2 cysts, obtained by laser microdissection. Of note, CPAM 1 and CPAM 2 form two distinct clusters. b. Comparison of proteomic profiles from CPAM 1 or CPAM 2 cyst epithelium, and control lung tissues (bronchi and alveoli). CPAM 2 cluster together and CPAM 1 samples cluster close to bronchi and are more distant from the alveoli. c. Comparison of proteomic profiles from epithelial lining of fetal canaliculi and bronchi (16 GW). d-e Hierarchical clustering was based on the entire set of proteins detected. d. Protein-set enrichment analysis of biological process from the epithelial lining of CPAM 1 and CPAM 2 cysts, obtained by laser microdissection. e. Protein-set enrichment analysis of cellular constituent from the epithelial lining of CPAM 1 and CPAM 2 cysts, obtained by laser microdissection. f-g. Hierarchical clustering of fetal samples was based on a selection of candidate GO terms. f. Selected protein-set enrichment analysis of biological process from the epithelial lining from fetal canaliculi and bronchi (16 GW). g. Selected protein-set enrichment analysis of cellular constituent from the epithelial lining from fetal canaliculi and bronchi (16 GW).

Fig. 4 — Protein profiles of CPAM cyst epithelium, bronchi, alveoli and fetal tissue. Proteins were obtained by microlaser dissection from 3 different patients. a-c Hierarchical clustering was based on the top 50 more abundant proteins. a. Comparison of proteomic profiles from the epithelial lining of CPAM 1 and CPAM 2 cysts, obtained by laser microdissection. Of note, CPAM 1 and CPAM 2 form two distinct clusters. b. Comparison of proteomic profiles from CPAM 1 or CPAM 2 cyst epithelium, and control lung tissues (bronchi and alveoli). CPAM 2 cluster together and CPAM 1 samples cluster close to bronchi and are more distant from the alveoli. c. Comparison of proteomic profiles from epithelial lining of fetal canaliculi and bronchi (16 GW). d-e Hierarchical clustering was based on the entire set of proteins detected. d. Protein-set enrichment analysis of biological process from the epithelial lining of CPAM 1 and CPAM 2 cysts, obtained by laser microdissection. e. Protein-set enrichment analysis of cellular constituent from the epithelial lining of CPAM 1 and CPAM 2 cysts, obtained by laser microdissection. f-g. Hierarchical clustering of fetal samples was based on a selection of candidate GO terms. f. Selected protein-set enrichment analysis of biological process from the epithelial lining from fetal canaliculi and bronchi (16 GW). g. Selected protein-set enrichment analysis of cellular constituent from the epithelial lining from fetal canaliculi and bronchi (16 GW).