Table 2.

Acute Kidney Injury (AKI) at two and seven days related to Proenkephalin A 119–159 (penKid)

	All patients (n = 588)	P-value	Quartile 1 (n = 147)	Quartile 2 (n = 147)	Quartile 3 (n = 147)	Quartile 4 (n = 147)	P for trend
penKid (pmol/L)a	77.9 (10.9–843.0)		10.9–56.9	57.0–77.9	78.1–119.4	120.0–843.0
AKI within 2 days
N events (% of total) b	79 (13.4%)		9 (6.1%)	6 (4.1%)	14 (9.5%)	50 (34.0%)
OR (95% CI)c	2.5 (1.9–3.3)	< 0.001	Reference	0.7 (0.2–1.9)	1.7 (0.7–4.2)	8.5 (3.7–19.2)	< 0.001
AKI within 7 days
N events (% of total)b	94 (15.9%)		10 (1.7%)	8 (1.4%)	17 (2.9%)	59 (10.0%)
OR (95% CI)c	2.5 (1.9–3.2)	< 0.001	Reference	0.8 (0.3–2.0)	1.9 (0.8–4.3)	9.5 (4.3–20.7)	< 0.001

^aPenKid presented as median (range), plasma concentration of proenkephalin A 119–159; OR, odds ratio; 95% CI, 95% confidence interval. ^bN (% of total) refers to the number of participants (proportion of total number participants) with Acute Kidney Injury (AKI) events. ^cOR (95% CI) are expressed as per z-score of log-transformed penKid and in analyses of quartiles the lowest quartile (quartile 1) was defined as the reference category and the OR (95% CI) for each of quartiles 2, 3 and 4 were compared with the reference quartile 1. Analyses were adjusted for age and sex