Table 1.

Pros and cons of skin biopsy and dermoscopy.

	Skin biopsy	Dermoscopy
Advantages	1. Provide universal validity based on long-term accumulated histopathological criteria	1. Identify optimal biopsy sites 2. Reduce unnecessary biopsy 3. Determine horizontal extent of skin lesion 4. Continue to observe lesion treatment
Disadvantages	1. Limitation of evaluating whole lesion by vertical information of specific region 2. Limitations of repeated practice due to pain, bleeding, and infection risk	1. Inherent depth limitation (upper dermis) 2. Difficulty implementing 3D image 3. No reflection of functional and dynamic information (blood flow velocity, oxygen saturation, etc.) of the skin