Table 1.
Vitamin D levels, fertility and pregnancy outcomes, complement levels, disease activity and co-presence of Hashimoto Thyroiditis in OAPS patients.
| OAPS patients (N = 76) | |||
|---|---|---|---|
| Vitamin D levels | Normal N = 17 (24.3%) | Hypovitaminosis D N = 59 (77.6%) | |
| Deficiency | Insufficiency | ||
| N = 38 (64.4%) | N = 21 (35.6%) | ||
| Implantation failure | 1 (5.9%) | 8 (21%) p = 0.2469 | 6 (28.6%) p = 0.2204 |
| 14 (23.7%), p = 0.1669 | |||
| IVF | 2 (11.8%) | 15 (39.5%) p = 0.0584 | 12 (57.1%)*p = 0.0063 |
| 27 (45.8%)*, p = 0.0116 | |||
| Low C3 levels | 1 (5.8%) | 12 (31.6%)*p = 0.0452 | 8 (38%)*p = 0.0263 |
| 20 (33.9%)*p = 0.0297 | |||
| Flares | 0 | 8 (21%)*p = 0.0479 | 14 (66.7%)*p = 0.001 **p = 0.0008 |
| 22 (37.3%)*, p = 0.0020 | |||
| Hashimoto thyroiditis | 0 | 17 (44.7%)*p = 0.0005 | 10 (47.6%)*p = 0.0008 |
| 27 (45.8%)*p = 0.003 | |||
| Placental insufficiency | 0 | 6 (15.8%) p = 0.1615 | 8 (38.1%) *p = 0.0047 |
| 14 (23.7%), *p = 0.0308 | |||
| PE (%) | 0 | 6 (15.8%) p = 0.1615 | 6 (28.6%)*p = 0.0241 |
| 12 (20.3%), p = 0.0531 | |||
| PTB (%) | 0 | 3 (7.9%) p = 1.000 | 2 (13.3%) p = 0.4922 |
| 5 (8.5%), p = 0.5812 | |||
Conception after IVF and the presence of implantation failure (inability to achieve a clinical pregnancy after transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles) were investigated as signs of compromised fertility. Placental insufficiency, preeclampsia and preterm birth were used to evaluate pregnancy outcomes. Presence of flares, defined as the relapse of symptoms that can compromise the skin, the joints, or any other compromised organ and complement C3 consumption were used to evaluate disease activity.
N, number of patients; %, percentage of patients; IVF, in vitro fertilization; PE, preeclampsia; PTB, preterm birth.
Different from patients with normal levels of vitamin D.
Different from patients with deficient levels of vitamin D. P <0.05 is considered statistically significant.